Lecture(Chromsomes and Human Genetics) Spr 2009

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Chromosomes and Human Genetics Chromosomes & Cancer ã Some genes on chromosomes control cell growth and division ã If something affects chromosome structure at or near these loci, cell division may spiral out of control ã This can lead to cancer Philadelphia Chromosome ã First abnormal chromosome to be associated with a cancer ã Reciprocal translocation ã Causes chronic myelogenous leukemia (CML) Genes ã Units of information about heritable traits ã In eukaryotes, distributed among ch
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  Chromosomes andChromosomes andHuman GeneticsHuman Genetics  Chromosomes & CancerChromosomes & Cancer ã Some genes on chromosomes control cellSome genes on chromosomes control cellgrowth and divisiongrowth and division ã If something affects chromosome structureIf something affects chromosome structureat or near these loci, cell division may spiralat or near these loci, cell division may spiralout of controlout of control ã  This can lead to cancer This can lead to cancer  Philadelphia ChromosomePhiladelphia Chromosome ã First abnormal chromosome to beFirst abnormal chromosome to beassociated with a cancerassociated with a cancer   ã Reciprocal translocationReciprocal translocation ã Causes chronic myelogenousCauses chronic myelogenousleukemia (CML)leukemia (CML)  GenesGenes ã Units of information about heritableUnits of information about heritabletraitstraits ã In eukaryotes, distributed amongIn eukaryotes, distributed amongchromosomeschromosomes ã Each has a particular locusEach has a particular locus –Location on a chromosomeLocation on a chromosome
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